Eligible Newtown residents will begin to receive their invitations for the Covid-19 vaccine.
It follows a test run over the past week by Powys Teaching Health Board as well as vaccines for health and care staff.
The vaccine will be administered at a hub in Newtown.
Powys is home to nearly 10,000 people aged 80 and over and it is expected to take several weeks to complete the programme through its three current hubs of Newtown, Builth Wells (opening on January 12) and Brecon.
The county’s health board has also reminded people not to contact their GP or pharmacist to request the COVID-19 vaccine, as everyone will receive a direct invitation.
In order to ensure that as many people as possible receive protection as soon as possible, Powys Teaching Health Board, along with all other health boards in Wales, said it is postponing the second dose of the vaccine for those health and care staff who have already received one dose.
Second doses will now be given 11 weeks after the first dose. This is following UK guidance and Welsh Government requirements.
However, even after vaccination with a first dose people are advised to continue to take measures to protect themselves: to keep a distance, wash their hands more often, and wear a face covering. The effects of the both vaccines on transmission is still unknown.
More information about COVID-19 vaccination in Powys is available from the Powys Teaching Health Board website: https://pthb.nhs.wales/coronavirus/covid-19-vaccination/